This is Malawi’s largest Wildlife Reserve and is 1802 square km. It is 115km from Lilongwe and 642km from Blantyre. It was established as a Wildlife Reserve in 1954.

Situated to the east of Kasungu National Park, Nkhotakota covers a huge area of escarpment wilderness and numerous drainage lines join three major north-easterly flowing rivers: the Dwangwa (on the northern boundary), the Bua and the Kaombe. Woodland (mostly miombo) is the main vegetation-type and there is some fine riparian forest along the major rivers. 

It has the following animals: - Elephant, Sable Antelope, Eland, Buffalo, Baboon, Hippo, Kudu, Hartebeest, Warthog, Zebra, and Grysbok.